I've received plenty of strange looks on public transport before for giggling at books madly (step forward My Family and Other Freaks by Carol Midgley and Have a Little Faith by Candy Harper) but I don't think I've ever got looks quite like the ones I did earlier today when I got to a particular point and without realising it must have said Oh good grief just tell her, tell her! out loud. The characters here are so likeable that I was desperate for them to get together, but it's clear to see why they were hesitant about taking such a major step after being friends for so long. Speaking of likeable characters, there's a wonderful supporting cast, and it's really interesting to read a novel with so many well-drawn and sympathetic people in it. The tension - and there's plenty of it - comes from the balance between the pair's feelings for each other and the challenges Kendall faces, especially, as an A list celebrity trying to deal with the paparazzi and adoring fans.
Despite the warning that this is for 17+ readers, there's nothing that I'd be unhappy for someone in their mid teens to read. There's one main sex scene which is fairly steamy but not really explicit. Having said that, the chemistry between the two narrators is absolutely sizzling - I was glad to be reading on Kindle as I think the paperback would surely catch fire! I also thought the Hollywood setting was very well described and felt incredibly realistic. It's also got one of the best endings I've read for ages, which had me jumping to my feet I was so excited. (Thankfully, I was off public transport by then!)
Due to dilution status of the urine, chemical concentrations measured in spot urine are frequently adjusted using correction factors, such as creatinine, specific gravity (SG), or osmolarity of the urine. Urinary correction factors, however, can be influenced dramatically by physiological changes such as pregnancy. Details about the variation of urine dilution over the course of pregnancy are not well characterized. In the present study, we investigated the variation of urine correction factors over time among the pregnant women of Korea (n = 69) and Thailand (n = 102). Creatinine, SG, and osmolality were determined in the urine samples obtained in each trimester of the participating women, and were compared by sampling time and by nationality. Implication of the variation in these correction factors was studied using phthalate metabolites measured in the urine samples as model chemicals. Urinary correction factors significantly varied across the trimesters especially in Korean pregnant women: urinary creatinine and osmolality were significantly lower in the third trimester (T3) urine than the first trimester (T1) urine. Urinary creatinine and SG of the T3 urine of Korean pregnant women were also significantly lower than those reported from the non-pregnant women who participated in Korean National Environmental Health Survey (KoNEHS) 2015-2017. Among Thai women, however, these correction factors were rather stable across the pregnancy. Differences in ethnicity, or in behavior such as water consumption amount may partly explain the differences. Temporal changes in these urine correction factors influenced the urinary phthalate metabolite concentrations adjusted for dilution, in both Korean and Thai pregnant women. The present observations show that the variations of urinary correction factors should be considered in exposure assessment of urinary chemicals for pregnant women, in order to circumvent potential bias due to physiological changes occurring during pregnancy, and to reduce errors in exposure classification and association.
Higher plants use the sedimentation of amyloplasts in statocytes as statolith to sense the direction of gravity during gravitropism. In Arabidopsis thaliana inflorescence stem statocyte, amyloplasts are in complex movement; some show jumping-like saltatory movement and some tend to sediment toward the gravity direction. Here, we report that a RING-type E3 ligase SHOOT GRAVITROPISM9 (SGR9) localized to amyloplasts modulates amyloplast dynamics. In the sgr9 mutant, which exhibits reduced gravitropism, amyloplasts did not sediment but exhibited increased saltatory movement. Amyloplasts sometimes formed a cluster that is abnormally entangled with actin filaments (AFs) in sgr9. By contrast, in the fiz1 mutant, an ACT8 semidominant mutant that induces fragmentation of AFs, amyloplasts, lost saltatory movement and sedimented with nearly statically. Both treatment with Latrunculin B, an inhibitor of AF polymerization, and the fiz1 mutation rescued the gravitropic defect of sgr9. In addition, fiz1 decreased saltatory movement and induced amyloplast sedimentation even in sgr9. Our results suggest that amyloplasts are in equilibrium between sedimentation and saltatory movement in wild-type endodermal cells. Furthermore, this equilibrium is the result of the interaction between amyloplasts and AFs modulated by the SGR9. SGR9 may promote detachment of amyloplasts from AFs, allowing the amyloplasts to sediment in the AFs-dependent equilibrium of amyloplast dynamics.
The Gravity of Us by Phil Stamper a relatable, and entertaining look at love, war, friendship, dating, and everything in between. If you are interested in reading this novel, you can download its ePub, PDF or Mobi formats just in a few clicks.
When an inverted pendulum approximates quiet standing, it is assumed that the distance between the center of pressure and the vertical projection of the center of mass on the ground (COP-COG) reflects the relationship between the controlling and controlled variables of the balance control mechanism, and that the center of mass acceleration (ACC) is proportional to COP-COG. As aging affects the control mechanism of balance during quiet standing, COP-COG must be influenced by aging and, as a result, ACC is influenced by aging as well. The purpose of this study was to test the hypotheses that aging results in an increased COP-COG amplitude and, as a consequence, that ACC becomes larger in the elderly than the young. Fifteen elderly and 11 young subjects stood quietly on a force platform with their eyes open or closed. We found that (1) the standard deviations of COP-COG and ACC were larger in the elderly than in the young, irrespective of the eye condition; (2) COP-COG is proportional to ACC in both age groups, i.e., the inverted pendulum assumption holds true for quiet standing. The results suggest that a change in the control strategy that is due to aging causes a larger COP-COG in the elderly and, as a consequence, that ACC becomes larger as well.
There is a high probability of iatrogenic perforation of the vertebral pedicle wall during the application of subaxial cervical pedicle screw (CPS). The goal of this study was to evaluate the accuracy of CPS insertion at C3-C7 in vitro using novel calipers based on the gravity line.
Nine cadaveric cervical spines underwent computed tomography scanning and preoperative design. A lateral fluoroscopic view was taken to measure the intra-operative sagittal angle by C-arm with hanging cross structured K-wires. By referring to the gravity line, caliper A was used to locate the entry point, while caliper B was employed to guide the screw insertion. Postoperative CT scans were performed to assess the accuracy of the screw placements, according to the Neo classification.
Two novel stainless steel calipers (caliper A and B), that referred to the gravity line instead of the superior or inferior vertebral endplate, were invented by the authors to locate the entry point and guide the stereoscopic insertion of CPS. The purpose of this in vitro study in cadaveric cervical spines was to evaluate the accuracy of subaxial CPS insertion using specially-made calipers and C-arm fluoroscopy.
The three-dimensional demonstration of insertion using caliper A and B. (A) Am obtained from the preoperative CT. (B) The realization of Am in the coronal plane. (C) Ag obtained from the intraoperative fluoroscopy. (D) The realization of Ag in the sagittal plane. (E) The ideal insertion of pedicle screw in the appropriate orientation. Red narrow arrow: the gravity line. White broad arrow: the ground plane.
In this experiment, a number model of gravitation and temperature is established by using Cavendish twist balance to test the gravity of shot at different temperature, the relationship between gravity and temperature is analyzed quantitatively, and it is concluded that, the higher the temperature of the object, the smaller the absolute value of gravity, and vice versa. It is further deduced that the greater the velocity of the object, the smaller the absolute value of gravity, and vice versa. This experiment fully explains why the gravity is very weak under the microscopic quantum scale and high temperature in the early universe. The result of this experiment is of great significance to improve the orbit calculation precision of the spacecraft (missile) of high temperature and ultra high speed.
Newton discovered the gravitation and established the formula of universal gravitation. This formula has been proved by numerous facts in the low-speed macro field. The current calculations of planets and missile orbits are based on Newtonian mechanics. However, there are still some problems in Newton's formula of universal gravitation, mainly in the following aspects: first, Newton's theory does not fully explain the precession of Mercury as it moves along its orbital to the perihelion. The Newtonian prediction (generated by the gravitational drag of other planets) has an error of 43 arc seconds per century compared with the actual observed precession. Second, Newton's theory predicts that the deflection of the light under the force of gravity is only half as much as the actual observation. Therefore, it can be said that Newtonian classical mechanics is a static mechanics (that is, the gravity calculation of two relatively static objects is accurate), only applicable to low speed 1 and macro field; while for the field of high speed and micro, there must be a large error in Newtonian mechanics formula, which must be corrected. 2b1af7f3a8